I found some great art and art museums on my trip to San Juan and Ponce. The museum in Ponce is well-worth the trip alone.
MACPR/Museo de Arte Contemporaneo Puerto Rico: Located on Ave. Ponce de Leon and Ave. Robert H. Todd, this is a museum devoted to contemporary art. There were two galleries on view but I really enjoyed the work.
The Museo de Arte de Puerto Rico: Of the two museums I saw, this was by far the best. The building is really beautiful and there is an emphasis on Puerto Rican artists. Outside there is a nice sculpture garden in the back. It is located at Avenida de Diego 299 in Santurce.
Espacio 1414: Located at Avenida Fernandez Juncos 1414, this is the Berezdivin Collection which is a significant collection of contemporary art with emphasis on Latin American art. The collection is open by appointment only. I was unaware of this, so I was unable to get in. You might enjoy visiting, so make a reservation.
The highlight of Ponce is the Museo de Arte de Ponce, which is in a beautiful building designed by Edward Durell Stone in 1965. It reopened in 2010 after a renovation and new addition. The collection includes works of the Italian Baroque, Spanish Golden Age and British Pre-Raphaelite periods. I enjoyed some contemporary works by a Cuban artist and a temporary show, from the Prado in Madrid, with works by El Greco, Goya and Velazquez. There is a nice restaurant for fine dining overlooking the sculpture garden.