There are some great hotel options to chose from with new ones under construction.
Tantalo: Hip Boutique Hotel in Casco Viejo with lively restaurant, bar, roof bar overlooking the city and large rooms each decorated by a different local artist. The staff could not have been more accommodating in helping with restaurant suggestions and reservations and arranging taxis and drivers. Bring your earplugs as sometimes street noise or noise from the bar might be an issue. I asked for a quiet room and liked Room #1 on the second floor. Loved the bedding also!!! A good breakfast was included in my room rate! Corner of Ave. B and Calle 8.
Other great hotels in Casco Viejo include Las Clementinas, which was a former 1930’s apartment building. The apartments have been transformed into six large suites. I didn’t stay there but people I met thought the rooms were excellent. Calle 11 y Avenida B.
I enjoyed meeting the owners of Casa Sucre Coffee House, Alyce and Rich Sherman, who are from Kansas City. They also own the highly recommended Casa Sucre Boutique Hotel in Casco Viejo, which is a five room bed and breakfast also with three apartments. The rooms were not available for viewing but I would check this out as well.
Waldorf Astoria Hotel: Just opened in March 2013, Hilton’s new Waldorf Astoria is quite contemporary and beautiful. It has a Peacock Alley lobby bar, Ginger Sushi Restaurant, BRIO Brasserie restaurant and Bungalow Terrace and Pool Bar with seating overlooking the pool and surrounding high rise towers.
Manrey Hotel: This is a boutique, design hotel, with lobby bar, second floor restaurant and a sleek rooftop pool and bar. It is on Calle Uruguay.
Just opened in late 2013 is the American Trade Hotel in Casco Viejo. It has received some great design buzz in Architectural Digest and other magazines, as it is a 50-room, boutique hotel in a building from 1917. It is part of the Ace Hotel group.
Also check out the newly opened La Concordia Boutique Hotel in Casco Viejo which is located in a restored building from the late 1800s. It has lovely rooms, restaurants and a rooftop bar.