Florence has many hotel options. Our top choice is the:
L’Hotel Tornabuoni Beacci: I have stayed at this hotel three times in the past. It is well-located at Tornabuoni 3. It used to be on one floor of an office building/old palazzo but now they have taken over the rest of the building and have added a number of new rooms. The staff is very helpful and there is an old world charm about the property.
Other hotel properties getting good press for design or comfort include Riva Lofts, Gallery Hotel Art, Relais Modern, Continentale, Hotel Torre Guelfa, Gran Hotel Villa Cora, Residence Hilde, El Salviatino and JK Place Firenze. The Villa Medici is another luxury option where I stayed on my first trip years ago.